Invitrogen™ NOD3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA565491

Product Code. 15968234

Description

Immunogen sequence: SNDSRIQRHRK ALLSKVGGGP ELGGPWHRLA SLLLVEGLTD LQLREHDFTQ VEATRGGGHP ARTVALDRLF LPLSRVSVPP RVSITIGV Highest antigen sequence identity to the following orthologs - mouse 79%, rat 74%.

NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-βB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.

Specifications

• Antigen: NOD3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NLRC3
• Gene Alias: CARD15-like protein; caterpillar 16.2; Caterpiller 16.2; caterpiller protein 16.2; CLR16.2; D230007K08Rik; mFLJ00348; NACHT, LRR and CARD domains-containing protein 3; NLR family CARD domain containing 3; NLR family CARD domain-containing protein 3; NLR family, CARD domain containing 3; NLR family, CARD domain containing 3, pseudogene 1; Nlrc3; Nlrc3-ps1; NOD3; NOD-like receptor C3; Nucleotide-binding oligomerization domain protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3; protein NLRC3; RGD1304902
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 197358
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q7RTR2
• Gene Symbols: NLRC3
• Immunogen: Recombinant Human NOD3. Recombinant protein control fragment (Product #RP-104842).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG