NKG2D/CD314 Antibody (1D11), Alexa Fluor™ 488, Novus Biologicals™

Mouse Monoclonal Antibody

Brand:  Novus Biologicals NB100-65956AF488

Product Code. 18248483

Description

NKG2D/CD314 Monoclonal specifically detects NKG2D/CD314 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.

Specifications

• Antigen: NKG2D/CD314
• Classification: Monoclonal
• Conjugate: Alexa Fluor 488
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Alias: CD314, CD314 antigen, D12S2489E, FLJ17759, FLJ75772, Killer cell lectin-like receptor subfamily K member 1, killer cell lectin-like receptor subfamily K, member 1, KLR, NK cell receptor D, NKG2-D, NKG2-D type II integral membrane protein, NKG2-D-activating NK receptor, NKG2DDNA segment on chromosome 12 (unique) 2489 expressed sequence
• Host Species: Mouse
• Purification Method: Protein G purified
• Regulatory Status: RUO
• Gene ID (Entrez): 22914
• Target Species: Human
• Form: Purified

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
• Clone: 1D11
• Dilution: Flow Cytometry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
• Gene Accession No.: P26718
• Gene Symbols: KLRK1
• Immunogen: NKL cells.
• Quantity: 0.25 mL
• Primary or Secondary: Primary
• Test Specificity: NB100-65956 is specific for CD314, also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. CD314 forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of CD314 include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding to CD314 results in NK cell activation and potent costimulation of effector T cells. Clone 1D11 is reported to inhibit T cell recognition of MICA (1,6).
• Content And Storage: Store at 4C in the dark.
• Isotype: IgG1

For Research Use Only