Nisin, 900 I.U./mg, Thermo Scientific™

Nisin, CAS # 1414-45-5, is a polycyclic peptide derived from and produced by Lactococcus lactis that shows antibacterial activity against gram-positive bacteria.

Brand:  Thermo Scientific Alfa Aesar J66370.14

Product Code. 15407709

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• Nisin is a broad-spectrum polycyclic peptide derived from and produced by Lactococcus lactis that shows antibacterial activity against gram-positive bacteria

Nisin binds lipid II in the cell membrane. After binding it can insert into the membrane, creating a pore

Nisin can efficiently inhibit the growth of gram-positive bacteria, and resistance is rarely observed

Application

• Nisin is commonly used as a selective compound in cell culture to isolate gram-negative bacteria, yeast, and molds (a type of fungus)

• It has been used in bioassays to study posttranslational modification

• This compound has the ability to bind and interfere with the permeability of the cytoplasmic membrane

• It is used to study the assembly and stability of nisin-lipid II pore complexes

• This compound is used in in vitro experiments to form targeted pores in cell membranes that are mediated by lipid II

Chemical Identifiers

• CAS: 1414-45-5
• Molecular Weight (g/mol): 3354.09
• InChI Key: NVNLLIYOARQCIX-OAXMGIFASA-N
• SMILES: CCC(C)C1C(=O)NC(=C)C(=O)NC(C(=O)NC(CSCC(C(=O)N1)NC(=O)C(=CC)NC(=O)C(C(C)CC)N)C(=O)NC2C(SCC(NC(=O)CNC(=O)C3CCCN3C2=O)C(=O)NC(CCCCN)C(=O)NC4C(SCC(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC4=O)C)CC(C)C)CCSC)C(=O)NC(CC(=O)N)C(=O)NC(CCSC)C(=O)NC(CCCCN)C(=O)NC5C(

• Molecular Formula: C143H230N42O37S7
• MDL Number: MFCD00131724
• PubChem CID: 131847819

Specifications

• CAS: 1414-45-5
• Quantity: 25g
• Molecular Formula: C143H230N42O37S7
• Boiling Point: 2967°C
• Solubility Information: Soluble in water
• SMILES: CCC(C)C1C(=O)NC(=C)C(=O)NC(C(=O)NC(CSCC(C(=O)N1)NC(=O)C(=CC)NC(=O)C(C(C)CC)N)C(=O)NC2C(SCC(NC(=O)CNC(=O)C3CCCN3C2=O)C(=O)NC(CCCCN)C(=O)NC4C(SCC(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC4=O)C)CC(C)C)CCSC)C(=O)NC(CC(=O)N)C(=O)NC(CCSC)C(=O)NC(CCCCN)C(=O)NC5C(
• PubChem CID: 131847819
• Chemical Name or Material: Nisin, 900 I.U./mg

• Color: Brown
• Flash Point: >110°C (230°F)
• MDL Number: MFCD00131724
• Merck Index: 14,6564
• InChI Key: NVNLLIYOARQCIX-OAXMGIFASA-N
• Molecular Weight (g/mol): 3354.09
• Formula Weight: 3354.06