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Niraparib tosylate, MedChemExpress

Product Code. 16485046
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Product Code. 16485046

Brand: Medchem Express HY10619B

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Description

MedChemExpress Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.

Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.

Specifications

Chemical Name or Material Niraparib tosylate
CAS 1038915-73-9
Color White
Purity Grade Notes Research
Molecular Formula C26H28N4O4S
Quantity 100 mg
Synonym MK-4827 tosylate
Solubility Information DMSO : 100 mg/mL (203.01 mM; ultrasonic and warming and heat to 60°C) ∣H2O : 1 mg/mL (2.03 mM; heat to 50°C)
SMILES NC(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C21)=O.O=S(C5=CC=C(C)C=C5)(O)=O
Molecular Weight (g/mol) 492.59
Formula Weight 492.59
Percent Purity 95.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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