Invitrogen™ NIK Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA141320

Product Code. 11598251

Description

Suggested positive control: antigen standard for MAP3K14 (transient overexpression lysate).

MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

Specifications

• Antigen: NIK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MAP3K14
• Gene Alias: aly; alymphoplasia; FTDCR1B; HS; HsNIK; Map3k14; Mitogen-activated protein kinase kinase kinase 14; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; NIK; protein kinase; serine/threonine-protein kinase NIK
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 9020
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q99558
• Gene Symbols: MAP3K14
• Immunogen: Synthetic peptide corresponding to amino acids 687-703 of human NIK.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG