Invitrogen™ NIFK Monoclonal Antibody (CL2240)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA531361

Product Code. 16384804

Description

Immunogen sequence: IDYDFPSLIL QKTESISKTN RQTSTKGQVL RKKKKKVSGT LDTPEKTVDS QGPTPVCTPT FLERRKSQVA ELNDDDKDDE I Highest antigen sequence indentity to the following orthologs: Mouse - 47%, Rat - 46%.

NIFK, also known as nucleolar protein interacting with the forkhead homolog protein, is a gene associated with several cancer types and is considered a potential prognostic biomarker. This gene functions within the nucleolus and plays a critical role in cellular proliferation, metastasis, and invasiveness, particularly noted in hepatocellular carcinoma (HCC) and colorectal cancer. NIFK expression is regulated via several pathways, including the MYC proto-oncogene pathway, and its silencing can lead to decreased fatty acid synthesis in colorectal cancer cells. Furthermore, it's involved in the regulation of innate immunity through pathways such as NF-kB in specific cancer cells. Due to its involvement in cancer progression, NIFK is being explored as a therapeutic target and holds promise for advancing precision medicine strategies across various cancer treatments.

Specifications

• Antigen: NIFK
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BYG3
• Gene Symbols: Nifk
• Immunogen: Recombinant protein fragment of Human NIFK (Product #RP-104083)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Clone: CL2240
• Conjugate: Unconjugated
• Gene: Nifk
• Gene Alias: AI852665; C130020J04Rik; hNIFK; Ki67ip; MKI67 (FHA domain) interacting nucleolar phosphoprotein; MKI67 FHA domain-interacting nucleolar phosphoprotein; MKI67IP; mNIFK; NIFK; NOPP34; nucleolar phosphoprotein Nopp34; nucleolar protein interacting with the FHA domain of MKI67; nucleolar protein interacting with the FHA domain of pKI-67; spermatogenesis-related protein (Srp)
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 84365
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid