Invitrogen™ Nicastrin Recombinant Rabbit Monoclonal Antibody (23GB1040), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA553745

Product Code. 30089570

Description

NCSTN (Nicastrin) is a gene that encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21.

Specifications

• Antigen: Nicastrin
• Classification: Recombinant Monoclonal
• Conjugate: Unconjugated
• Gene: NCSTN
• Gene Alias: 9430068N19Rik; AA727311; anterior pharynx-defective 2; Aph2; ATAG1874; D1Dau13e; Kiaa0253; mKIAA0253; NCSTN; Nct; Nicastrin; OTTHUMP00000031840; UNQ1874/PRO4317
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23385, 289231, 59287
• Content And Storage: -20°C
• Form: Liquid

• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Clone: 23GB1040
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P57716, Q8CGU6, Q92542
• Gene Symbols: NCSTN
• Immunogen: A synthetic peptide of human Nicastrin (696-709AA).
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG