NGEF Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16801404	Proteintech 13271-1-AP-20UL	20 μL
16891394	Proteintech 13271-1-AP-150UL	150 μL

Description

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.

Specifications

• Antigen: NGEF
• Applications: Immunoprecipitation, Western Blot, Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: Q8CHT1, Q8N5V2
• Gene ID (Entrez): 25791, 53972
• Immunogen: NGEF Fusion Protein Ag3967
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: NGEF

• Concentration: 0.33 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: EPHEXIN, Ephexin 1, NGEF
• Gene Symbols: NGEF
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody