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NF-M Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16810245 Shop All Proteintech Products
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20 μL
150 μL
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20µL
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16810245 20 μL 20µL
16800245 150 μL 150µL
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Product Code. 16810245 Supplier Proteintech Supplier No. 206641AP20UL

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Description

Rabbit Polyclonal Antibody

The antibody is specific to NEFM.

Neurofilaments (NFs) are a type of intermediate filament (IF) expressed almost exclusively in neuronal cells, and in those cells most prominently in large axons. NFs, in most vertebrates, are composed of three different polypeptide chains with different molecular weights - neurofilament medium protein (NF-M), high (NF-H) and light protein (NF-L), which share sequence and structural similarity in a coiled-coil core domain, but differ in the length and sequence of their N-termini and more dramatically of their C-termini which in the case of NF-M and NF-H form the flexible extensions that link NFs to each other and to other elements in the cytoplasm. NF-M protein tail-mediated interactions of neurofilaments are critical for size and cytoskeletal architecture of axons, and are mediated, in part, by the highly phosphorylated tail domain of this protein. NF-M phosphorylation and O-GlcNAcylation are regulated reciprocally and affect its translocation and filament formation and function. Antibodies to the various neurofilament subunits are very useful cell type markers since the proteins are among the most abundant of the nervous system, are expressed only in neurons and are biochemically very stable.

Specifications

Antigen NF-M
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Immunoprecipitation, Immunofluorescence
Classification Polyclonal
Concentration 0.35 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene NEFM
Gene Accession No. P07197, P08553, P12839
Gene Alias NEF3, NEFM, NF M, NFM
Gene Symbols Nefm
Host Species Rabbit
Immunogen Peptide
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18040, 24588, 4741
Target Species Rat, Mouse, Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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