Invitrogen™ NF-H Monoclonal Antibody (NF-05)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA110441

Product Code. 12322443

Description

This antibody recognizes a nonphosphorylated epitope of neurofilament heavy protein (NF-H), a 210 kDa intracellular structural protein of Intermediate Filament Proteins family. NF-H is mainly expressed in the central and peripheral nervous system and reproductive system and is biochemically very stable. It will not cross-react with mouse.

Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-H has an important role in mature axons and is involved in amyotrophic lateral sclerosis (ALS).

Specifications

• Antigen: NF-H
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene Accession No.: P12036, P12037, P16884
• Gene Symbols: Nefh
• Immunogen: Pig brain neurofilament protein-enriched fraction after depolymerization of microtubules.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat, Pig
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunohistochemistry (Frozen), Western Blot
• Clone: NF-05
• Conjugate: Unconjugated
• Gene: Nefh
• Gene Alias: 200 kDa neurofilament protein; CMT2CC; heavy neurofilament protein; I79_012512; intermediate filament protein; KIAA0845; LOW QUALITY PROTEIN: neurofilament heavy polypeptide; mKIAA0845; NEF3; Nefh; nefh.L; neurofilament; neurofilament 200kDa; neurofilament heavy; neurofilament heavy L homeolog; neurofilament heavy polypeptide; neurofilament heavy polypeptide-like; neurofilament triplet H protein; neurofilament, heavy polypeptide; neurofilament, heavy polypeptide 200kDa; neurofilament, heavy polypeptide L homeolog; neurofilament-H; NF 200 kD; NF200; Nfh; NF-H; NHC; XELAEV_18007418mg
• Host Species: Mouse
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100156492, 24587, 4744
• Content And Storage: 4°C, do not freeze
• Form: Liquid