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  5. Tocris Bioscience™ Nexinhib20

Tocris Bioscience™ Nexinhib20
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Product Code. 18769976
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Quantity:
5 mg
25 mg
Unit Size:
25mg
5mg
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Product Code. 18769976

Brand: Tocris Bioscience™ 6089/25

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This item is not returnable. View return policy

Description

Rab27 inhibitor (IC50 = 330 nM); inhibits neutrophil exocytosis; active in vivo

Nexinhib20 is a Rab27 inhibitor (IC50 = 330 nM); inhibits Rab27a-JFC1 binding. Selectively inhibits neutrophil exocytosis, with no significant effect on other important innate immune responses including phagocytosis. Suppresses extracellular production of superoxide anion and cytochrome b plasma membrane expression. Also inhibits upregulation of adhesion molecules CD11b and CD66b. Displays in vivo anti-inflammatory activity.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 4,4-Dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one
CAS 331949-35-0
Quantity 25 mg
Molecular Formula C15H16N4O3
Formula Weight 300.31
Purity 98%
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