Invitrogen™ Neurturin Polyclonal Antibody

Sheep Polyclonal Antibody

Brand:  Invitrogen™ PA118368

Product Code. 11562012

Description

Reconstitute in 100 μL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently and termed GDNFR-b, Ret ligand 2 (RETL2) or TGF-beta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFR-a-2 recently. NTN binds to and forms a complex with GFR-a-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.

Specifications

• Antigen: Neurturin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NRTN
• Gene Alias: neurturin; NRTN; NTN; prepro-neurturin
• Host Species: Sheep
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Frozen), Western Blot
• Concentration: Conc. Not Determined
• Formulation: Whole serum with no preservative
• Gene Accession No.: P97463, Q99748
• Gene Symbols: NRTN
• Immunogen: Recombinant human Neurturin (aa 96-197).
• Regulatory Status: RUO
• Gene ID (Entrez): 18188, 4902, 84423
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized