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Neurturin Polyclonal Antibody, Invitrogen™
Sheep Polyclonal Antibody
Brand: Invitrogen PA118368
Code : LD
Additional Details : Weight : 0.01000kg
Description
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently and termed GDNFR-b, Ret ligand 2 (RETL2) or TGF-beta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFR-a-2 recently. NTN binds to and forms a complex with GFR-a-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.Specifications
Neurturin | |
Polyclonal | |
Unconjugated | |
NRTN | |
neurturin; NRTN; NTN; prepro-neurturin | |
Sheep | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
ELISA, Immunohistochemistry (Frozen), Western Blot | |
Conc. Not Determined | |
whole serum with no preservative | |
P97463, Q99748 | |
NRTN | |
Recombinant human Neurturin. | |
RUO | |
18188, 4902, 84423 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |