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Invitrogen™ Neurturin Polyclonal Antibody

Product Code. 12868082
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Quantity:
100 μg
Unit Size:
100µg
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12868082 100 μg 100µg
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Product Code. 12868082 Supplier Invitrogen™ Supplier No. PA519867

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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~14kDa. A suggested positive control is Jurkat cell lysate. PA5-19867 can be used with blocking peptide PEP-0005.

Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently and termed GDNFR-b, Ret ligand 2 (RETL2) or TGF-beta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFR-a-2 recently. NTN binds to and forms a complex with GFR-a-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Neurturin
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene NRTN
Gene Accession No. Q99748
Gene Alias neurturin; NRTN; NTN; prepro-neurturin
Gene Symbols NRTN
Host Species Rabbit
Immunogen A peptide corresponding to amino acids 178 to 193 of human Neurturin.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4902
Target Species Human
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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