Invitrogen™ NELF Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA560674

Product Code. 15728501

Description

Immunogen sequence: KLNVYHKGAK IWKMLIFCQG GPGHLYLLKN KVATFAKVEK EEDMIHFWKR LSRLMSKVNP EPNVIHIMGC YILGNPNGEK LFQNLRTLMT PYRVTFESPL ELSAQGKQMI ETYFDFRL Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

NELF (nasal embryonic luteinizing hormone-releasing hormone factor) is a 530 amino acid transcription factor involved in the migration of LHRH neurons, outgrowth of olfactory axons and suppression of transcription elongation. NELF is found in the peripheral and central nervous system during embryonic development, and is highly expressed in adult testis, kidney and brain. Known to couple NMDA receptor signaling to the nucleus, NELF knockdown impaired GnRH neuronal migration of NLT cells in vitro and the gene encoding NELF has been linked to the development of Idiopathic hypogonadotropic hypogonadism (IHH), a disorder resulting in impaired pubertal maturation and reproductive function.

Specifications

• Antigen: NELF
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NSMF
• Gene Alias: HH9; Jac; Jacob; Jacob protein; Juxtasynaptic attractor of caldendrin on dendritic boutons protein; nasal embryonic LHRH factor; Nasal embryonic luteinizing hormone-releasing hormone factor; NELF; NMDA receptor synaptonuclear signaling and neuronal migration factor; NSMF
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26012
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6X4W1
• Gene Symbols: NSMF
• Immunogen: Recombinant protein corresponding to Human NSMF. Recombinant protein control fragment (Product #RP-93053).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG