Invitrogen™ NEK8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA559248

Product Code. 15727111

Description

Immunogen sequence: LSTERELFAW GRGDSGRLGL GTRESHSCPQ QVPMPPGQEA QRVVCGIDSS MILTVPGQAL ACGSNRFNKL G Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 86%.

NEK8 serine/threonine kinase or NIMA-related kinase 8 is related to NIMA (never in mitosis, gene A) of Aspergillus nodulins and may play a role in cell cycle progression from G2 to M phase. NEK8 is part of a complex of ciliary proteins required for renal and cardiovascular development. NEK8 interacts with polycystin signal transduction pathways and may control the targeting of these ciliary proteins. Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia.Defects in NEK8 are the cause of nephronophthisis type 9 (NPHP9) [MIM:613824]. NPHP9 is an autosomal recessive disorder resulting in end-stage renal disease. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.

Specifications

• Antigen: NEK8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NEK8
• Gene Alias: 4632401F23Rik; b2b1449Clo; JCK; juvenile cystic kidney; NEK 8; NEK12A; Nek8; nephrocystin 9; never in mitosis A-related kinase 8; NIMA (never in mitosis gene a)- related kinase 8; NIMA (never in mitosis gene a)-related expressed kinase 8; NIMA related kinase 8; NIMA-family kinase NEK8; NIMA-related expressed kinase 8; NIMA-related kinase 12a; NIMA-related kinase 8; nima-related protein kinase 12a; NimA-related protein kinase 8; NPHP9; RHPD2; Serine/threonine-protein kinase Nek8; serine/thrionine-protein kinase NEK8
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 284086
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q86SG6
• Gene Symbols: NEK8
• Immunogen: Recombinant protein corresponding to Human NEK8. Recombinant protein control fragment (Product #RP-98305).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG