Invitrogen™ NEK3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA560284

Product Code. 15728121

Description

Immunogen sequence: RGGSVIKYSK NTTRKQWLKE TPDTLLNILK NADLSLAFQT YTIYRPGSEG FLKGPLSEET EASDSVDGGH DSVILDPERL EPGLDEED Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 74%.

NIMA was originally shown in Aspergillus nidulans to be necessary for entry into mitosis. NIMA-related mammalian proteins have since been identified as Nek1, Nek2, Nek3 and Nek4 (also designated STK2 or NRK2). High expression of Nek1 is seen in male and female germ cell lines of mouse. Nek2 is the closest known mammalian relative to NIMA. Like NIMA, Nek2 expression peaks at the G2 to M phase transition. Nek3 is a predominantly cytoplasmic enzyme that was detectable in all organs studied. Levels of Nek3 seem to remain unchanged throughout the cell cycle, but appear to be elevated in G0-arrested, quiescent fibroblasts. In developing testicular germ cells, differential patterns of expression were seen for Nek1, Nek2 and Nek4, indicating possible overlapping, but non-identical functions.

Specifications

• Antigen: NEK3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Nek3
• Gene Alias: glycogen synthase A kinase; HSPK 36; HSPK36; hydroxyalkyl-protein kinase; Nek3; Never in mitosis A-related kinase 3; NIMA (never in mitosis gene a)-related expressed kinase 3; NIMA (never in mitosis gene a)-related kinase 3; NIMA related kinase 3; NIMA-related expressed kinase 3; NIMA-related kinase 3; nimA-related protein kinase 3; phosphorylase B kinase kinase; serine/threonine-protein kinase Nek3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4752
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.7 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P51956
• Gene Symbols: Nek3
• Immunogen: Recombinant protein corresponding to Human NEK3. Recombinant protein control fragment (Product #RP-99574).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG