Invitrogen™ NEIL3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA550028

Product Code. 15693955

Description

The antibody detects endogenous levels of total NEIL3 protein.

DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.

Specifications

• Antigen: NEIL3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Neil3
• Gene Alias: AI449477; BC034753; C85903; DNA glycosylase FPG2; DNA glycosylase hFPG2; DNA glycosylase/AP lyase Neil3; Endonuclease 8-like 3; endonuclease VIII-like 3; FGP2; FLJ10858; FPG2; hFPG2; hNEI3; nei endonuclease VIII-like 3; nei endonuclease VIII-like 3 (E. coli); nei like 3; nei like 3 (E. coli); nei like DNA glycosylase 3; NEI3; Neil3; nei-like DNA glycosylase 3; nei-like protein 3; RGD1310562; ZGRF3; zinc finger, GRF-type containing 3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 234258, 290729, 55247
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 30% glycerol, 0.87% NaCl and 0.01% sodium azide; pH 7.4
• Gene Accession No.: Q8K203, Q8TAT5
• Gene Symbols: Neil3
• Immunogen: Synthesized peptide derived from internal of human NEIL3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG