NEIL1 Mouse anti-Human, CoraLite 488, Clone: 1C6D6, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech CL488-67012-100UL

Product Code. 17204726

Description

NEIL1, also named as NEH1 and FPG1, belongs to the FPG family. It is involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. NEIL1 acts as DNA glycosylase that recognizes and removes damaged bases. It has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. NEIL1 has marginal activity towards 8-oxoguanine. It has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. It cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. NEIL1 has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. The increased BER activity of NEILs may represent an adaptive response against ROS-induced DNA damage resulting from aniline exposure, and could be an important mechanism for the removal of oxidative DNA lesions. (PMID:21145906)

Specifications

• Antigen: NEIL1
• Classification: Monoclonal
• Concentration: 1000 μg/mL
• Host Species: Mouse
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Isotype: IgG2a

• Applications: Immunofluorescence
• Clone: 1C6D6
• Conjugate: CoraLite 488
• Quantity: 100 μL
• Gene ID (Entrez): 79661
• Form: Liquid