Invitrogen™ NEDD8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA588187

Product Code. 16516501

Description

Immunogen sequence: MLIKVKTLTG KEIEIDIEPT DKVERIKERV EEKEGIPPQQ QRLIYSGKQM NDEKTAADYK ILGGSVLHLV LALRGGGGLR Q; Positive Samples: Mouse brain, Mouse kidney, Rat kidney, Rat brain; Cellular Location: Nucleus.

NEDD8 is a ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.

Specifications

• Antigen: NEDD8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Nedd8
• Gene Alias: nedd8; NEDD-8; NEDD8 ubiquitin like modifier; nedd8.L; nedd8.S; neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; neural precursor cell expressed, developmentally down-regulated 8; neural precursor cell expressed, developmentally down-regulated 8 L homeolog; neural precursor cell expressed, developmentally down-regulated 8 S homeolog; neural precursor cell expressed, developmentally down-regulated gene 8; neural precursor cell-expressed developmentally down-regulated; Rub1; si:zc14a17.5; ubiquitin; ubiquitin-like protein Nedd8; XELAEV_18007009mg
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18002, 25490
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.51 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P29595, Q71UE8
• Gene Symbols: Nedd8
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-81 of human NEDD8 (NP_0061471).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat, Rat
• Product Type: Antibody
• Isotype: IgG