Invitrogen™ Nectin 2 Monoclonal Antibody (R2.525)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA135890

Product Code. 11525092

Description

Mouse anti Human CD112 antibody, clone R2-525 recognizes CD112, also known as Poliovirus Receptor Related 2, PRR2 or Nectin-2, a surface molecule originally reported to be homologous to CD155, the poliovirus receptor (Lopez et al. 1998). PRR2 expression is restricted to the myelo-monocytic and megakaryocytic lineages. PRR2 expression has also been detected on haematopoeitic progenitors expressing CD34.

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Specifications

• Antigen: Nectin 2
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q92692
• Gene Symbols: NECTIN2
• Immunogen: Proprietary immunogen.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation
• Clone: R2.525
• Conjugate: Unconjugated
• Gene: NECTIN2
• Gene Alias: AI325026; AI987993; CD112; herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; hveB; mHveB; MPH; Murine herpes virus entry protein B; murine herpesvirus entry protein B; nectin cell adhesion molecule 2; Nectin2; Nectin-2; Poliovirus receptor homolog; poliovirus receptor related 2; poliovirus receptor-like 2; poliovirus receptor-related 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); poliovirus receptor-related protein 2; poliovirus sensitivity; PRR2; Pvr; Pvrl2; PVRR2; Pvs
• Host Species: Mouse
• Purification Method: purified
• Regulatory Status: RUO
• Gene ID (Entrez): 5819
• Content And Storage: 4°C
• Form: Liquid