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Invitrogen™ NDUFS2 Recombinant Rabbit Monoclonal Antibody (K01_2N47)

Description
Immunogen sequence: WDLRKTQPYD VYDQVEFDVP VGSRGDCYDR YLCRVEEMRQ SLRIIAQCLN KMPPGEIKVD DAKVSPPKRA EMKTSMESLI HHFKLYTEGY QVPPGATYTA IEAPKGEF Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%, Pig - 98%, Cynomolgus monkey - 98%.
The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase. Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specifications
Specifications
| Antigen | NDUFS2 |
| Applications | Immunohistochemistry (Paraffin), Western Blot |
| Classification | Recombinant Monoclonal |
| Clone | K01_2N47 |
| Concentration | 1 mg/mL |
| Conjugate | Unconjugated |
| Formulation | 50mM tris glycine with 40% glycerol, 0.05% BSA, 150mM NaCl and 0.01% sodium azide; pH 7.4 |
| Gene | Ndufs2 |
| Gene Accession No. | O75306 |
| Gene Alias | AL033311; CI-49; CI-49kD; comp; complex 1, mitochondrial respiratory chain, 49-KD subunit; complex I 49kDa subunit; complex I-49kD; EMBL:AAH82067.1}; NADH dehydrogenase (ubiquinone) Fe-S protein 2; NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; NADH:ubiquinone oxidoreductase core subunit S2; NADH-coenzyme Q reductase; NADH-ubiquinone oxidoreductase 49 kDa subunit; NADH-ubiquinone oxidoreductase NDUFS2 subunit; Ndufs2; ndufs2 {ECO:0000312; unnamed protein product |
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