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Invitrogen™ NDUFAF2 Polyclonal Antibody

Product Code. 12858952
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Quantity:
100 μg
Unit Size:
100µg
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12858952 100 μg 100µg
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Product Code. 12858952 Supplier Invitrogen™ Supplier No. PA520831

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Description

Rabbit Polyclonal Antibody

A suggested positive control is Raji cell lysate. PA5-20831 can be used with blocking peptide PEP-0945.

Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kappa-B-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NDUFAF2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Ndufaf2
Gene Accession No. Q8N183
Gene Alias 1810058I14Rik; B17.2L; B17.2-like; B172L; B172-like; C86051; mimitin; mimitin, mitochondrial; MMTN; Myc-induced mitochondria protein; Myc-induced mitochondrial protein; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2; NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; NADH dehydrogenase 1 alpha subcomplex assembly factor 2; NADH:ubiquinone oxidoreductase complex assembly factor 2; NDUFA12L; NDUFA12-like protein; Ndufaf2; RGD1560158
Gene Symbols Ndufaf2
Host Species Rabbit
Immunogen A 14 amino acid peptide from near the carboxy terminus of human Mimitin.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 91942
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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