Invitrogen™ NDUFAF2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA583895

Product Code. 16390845

Description

Immunogen sequence: MGWSQDLFRA LWRSLSREVK EHVGTDQFGN KYYYIPQYKN WRGQTIREKR IVEAANKKEV DYEAGDIPTE WEAWIRRTRK TPP Highest antigen sequence indentity to the following orthologs: Mouse - 80%, Rat - 75%.

Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kappa-B-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.

Specifications

• Antigen: NDUFAF2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ndufaf2
• Gene Alias: 1810058I14Rik; B17.2L; B17.2-like; B172L; B172-like; C86051; mimitin; mimitin, mitochondrial; MMTN; Myc-induced mitochondria protein; Myc-induced mitochondrial protein; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2; NADH dehydrogenase (ubiquinone) complex I, assembly factor 2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; NADH dehydrogenase 1 alpha subcomplex assembly factor 2; NADH:ubiquinone oxidoreductase complex assembly factor 2; NDUFA12L; NDUFA12-like protein; Ndufaf2; RGD1560158
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 91942
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8N183
• Gene Symbols: Ndufaf2
• Immunogen: Recombinant protein corresponding to Human NDUFAF2. Recombinant protein control fragment (Product #RP-104844).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG