Invitrogen™ NCK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5104540

Product Code. 16610995

Description

Antibody detects endogenous levels of total NCK2.

The NCK family of SH2/SH3 adaptor proteins consists of two members, NCK1 and NCK2, which couple tyrosine kinase signaling, including the EGF and PDGF receptor-pathways, to downstream signaling proteins. The NCK2 protein binds human PDGFR-b (Tyr-1009); overexpression of NCK2 inhibits PDGF-induced membrane ruffling and lamellipod formation.

Specifications

• Antigen: NCK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NCK2
• Gene Alias: 4833426I10Rik; cytoplasmic protein NCK2; Grb4; growth factor receptor-bound protein 4; NCK adaptor protein 2; NCK2; Nck-2; NCKbeta; non-catalytic region of tyrosine kinase adaptor protein 2; noncatalytic region of tyrosine kinase, beta; SH2/SH3 adaptor protein NCK-beta
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17974, 8440
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O43639, O55033
• Gene Symbols: NCK2
• Immunogen: A synthesized peptide derived from human NCK2(Accession O43639), corresponding to amino acid residues Y164-L214.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG