Invitrogen™ NCK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA596788

Product Code. 16579621

Description

Immunogen sequence: MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN SLKKGSLVKN LKDTLGLGKT RRKTSARDAS PTPSTDAEYP ANGSGADRIY DLNIPAFVKF AYVAEREDEL SLVKGSRVTV MEKCSDGWWR GSYNGQIGWF PSNYVLEEVD EAAAESPSFL SLRKGASLSN GQGSRVLHVV QTLYPFSSVT EEELNFEKGE TMEVIEKPEN DPEWWKCKNA RGQVGLVPKN YVVVLSDGPA LHPAHAPQIS YTGPSSSGRF AGREWYYGNV TRHQAECALN ERGVEGDFLI RDSESSPSDF SVSLKASGKN KHFKVQLVDN VYCIGQRRFH TMDELVEHYK KAPIFTSEHG EKLYLVRALQ; Positive Samples: 293T, Mouse lung, Rat brain; Cellular Location: Cytoplasm, Endoplasmic reticulum.

The NCK family of SH2/SH3 adaptor proteins consists of two members, NCK1 and NCK2, which couple tyrosine kinase signaling, including the EGF and PDGF receptor-pathways, to downstream signaling proteins. The NCK2 protein binds human PDGFR-b (Tyr-1009); overexpression of NCK2 inhibits PDGF-induced membrane ruffling and lamellipod formation.

Specifications

• Antigen: NCK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NCK2
• Gene Alias: 4833426I10Rik; cytoplasmic protein NCK2; Grb4; growth factor receptor-bound protein 4; NCK adaptor protein 2; NCK2; Nck-2; NCKbeta; non-catalytic region of tyrosine kinase adaptor protein 2; noncatalytic region of tyrosine kinase, beta; SH2/SH3 adaptor protein NCK-beta
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17974, 316369, 8440
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 4.95 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O43639, O55033
• Gene Symbols: NCK2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-380 of human NCK2 (NP_0035722).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG