Invitrogen™ NCAPD2 Recombinant Rabbit Monoclonal Antibody (24GB75)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30276468	Invitrogen™ MA557514	100 μL
30275282	Invitrogen™ MA557515	20 μL

Beskrivelse

NCAPD2 Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). [UniProt]

Tekniske data

• Antigen: NCAPD2
• Content And Storage: -20°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human, Mouse, Rat
• Gene: NCAPD2
• Gene Alias: 2810406C15Rik; 2810465G24Rik; Capd2; CAP-D2; chromosome condensation related SMC associated protein 1; chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; CNAP1; Condensin complex subunit 1; hCAP-D2; KIAA0159; mCAP-D2; mKIAA0159; Ncapd2; Non-SMC condensin I complex subunit D2; non-SMC condensin I complex, subunit D2; RGD1562596; XCAP-D2 homolog
• Gene Symbols: NCAPD2
• Primary or Secondary: Primary
• Purification Method: Affinity chromatography

• Clone: 24GB75
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q15021, Q8K2Z4
• Gene ID (Entrez): 362438, 68298, 9918
• Immunogen: A synthesized peptide derived from human CNAP1 (aa 100-200).
• Product Type: Antibody