Invitrogen™ NBS1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA587503

Product Code. 16545981

Description

Immunogen sequence: NNLFTDTDLK SIVKNSASKS HAAEKLRSNK KREMDDVAIE DEVLEQLFKD TKPELEIDVK VQKQEEDVNV RKRPRMDIET NDTFSDEAVP ESSKISQENE IGKKRELKED SLWSAKEISN NDKLQDDSEM LPKKLLLTEF RSLVIKNSTS RNPSGINDDY GQLKNFKKFK KVTYPGAGKL PHIIGGSDLI AHHARKNTEL EEWLRQEMEV QNQHAKEESL ADDLFRYNPY LKRRR Positive Samples: U-87MG, HeLa, HepG2, mouse liver; Cellular Location: Chromosome, Nucleus, PML body, telomere.

The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.

Specifications

• Antigen: NBS1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NBN
• Gene Alias: AT V1; AT V2; ATV; AT-V1; AT-V2; Cell cycle regulatory protein p95; FLJ10155; I79_012607; MGC87362; Nbn; NBS; NBS1; nibrin; Nijmegen breakage syndrome 1 (nibrin); Nijmegen breakage syndrome protein 1; Nijmegen breakage syndrome protein 1 homolog; OTTHUMP00000204088; P95; p95 protein of the MRE11/RAD50 complex; p95-NBS1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27354, 4683, 85482
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: O60934, Q9JIL9, Q9R207
• Gene Symbols: NBN
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 520-754 of human NBS1/NBN (NP_0024762).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG