Invitrogen™ NAT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA595422

Product Code. 16394685

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: A431 whole cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Arylamine N-acetyltransferases (NAT-1 and NAT-2) catalyze N- or O-acetylation of heterocyclic and arylamine substrates in the detoxification of a wide array of drugs. Certain alleles causing high N-acetyltransferase activity have been associated with colon and urinary bladder cancers, as NATs also bioactivate several known carcinogens. Both NAT-1 and NAT-2 are cytoplasmic proteins and play an active role in the detoxification of many arylamine and hydrazine drugs. N-acetylation polymorphism is determined by the level of NAT activity in liver tissues, and has been linked to the action and toxicity of drugs that contain amines. Human NAT-1 is the functional homolog of rodent NAT-2, while human NAT-2 is the functional homolog of rodent NAT-1.

Specifications

• Antigen: NAT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NAT1
• Gene Alias: AAC1; Arylamide acetylase 1; arylamine N-acetyltransferase 1; AT-1; MNAT; Monomorphic arylamine N-acetyltransferase; N(alpha)-acetyltransferase 15, NatA auxiliary subunit; N-acetyl transferase 1; N-acetyl transferase 1, liver, blood; N-acetyltransferase (arylamine N-acetyltransferase); N-acetyltransferase 1; N-acetyltransferase 1 (arylamine N-acetyltransferase); N-acetyltransferase type 1; Nat; Nat1; NAT-1; NATI
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene Accession No.: P18440
• Gene Symbols: NAT1
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human NAT1 (172-201aa NEEFLHSDLLEDSKYRKIYSFTLKPRTIED).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG