ACROBiosystems Human LIGHT / TNFSF14 Protein, Fc tag

Product Code. 16427849

Brand: ACROBiosystems LITH5265100ug

Description

Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.

This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 44.7 kDa. The protein migrates as 50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Specifications

• Accession Number: NP 003798.2
• Molecular Weight (g/mol): 44.7 kDa
• Quantity: 100 μg
• Source: Human LIGHT, Fc tag (LIT-H5265) is expressed from human 293 cells (HEK293). It contains AA Asp 74 - Val 240 (Accession # O43557-1).
• Immunogen: Asp 74 - Val 240
• Storage Requirements: -20°C
• Gene Alias: CD258 antigen,CD258,HVEM-L,LIGHT,LTg,TNFSF14,TR2,HVEML
• Common Name: LIGHT
• Conjugate: Unconjugated
• Species: Human
• Protein Tag: Fc Tag
• Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Endotoxin Level: Less than 1.0 EU / μg by the LAL method.
• Expression System: HEK293
• Form: Powder
• Protein Subtype: Immune Checkpoint Proteins
• Purity or Quality Grade: >85% as determined by SDS-PAGE