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Invitrogen™ NALP7 Polyclonal Antibody

Product Code. 12829172
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Quantity:
100 μg
Unit Size:
100µg
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12829172 100 μg 100µg
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Product Code. 12829172 Supplier Invitrogen™ Supplier No. PA521023

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human brain tissue lysate. PA5-21023 can be used with blocking peptide PEP-1137.

NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1-b secretion and is a feedback regulator of interleukin-1-b secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NALP7
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene NLRP7
Gene Accession No. Q8WX94
Gene Alias CLR19.4; HYDM; NACHT, leucine rich repeat and PYD containing 7; NACHT, LRR and PYD containing protein 7; NACHT, LRR and PYD domains-containing protein 7; NALP7; NLR family pyrin domain containing 7; NLR family, pyrin domain containing 7; NLRP7; NOD12; Nucleotide-binding oligomerization domain protein 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7; PAN7; PYPAF3; PYRIN-containing APAF1-like protein 3
Gene Symbols NLRP7
Host Species Rabbit
Immunogen An 18 amino acid peptide near the amino terminus of human NALP7.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 199713
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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