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Invitrogen™ NALP2 Polyclonal Antibody

Product Code. 12868242
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Quantity:
100 μg
Unit Size:
100µg
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12868242 100 μg 100µg
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Product Code. 12868242 Supplier Invitrogen™ Supplier No. PA520213

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Description

Rabbit Polyclonal Antibody

A suggested positive control is PC-3 cell lysate. PA5-20213 can be used with blocking peptide PEP-0348.

NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1-b-processing activity and is thought to function as a modulator of NF-kappa-B and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NALP2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene NLRP2
Gene Accession No. Q9NX02
Gene Alias CLR19.9; E330007A02Rik; FLJ20510; LOC684545; NACHT, leucine rich repeat and PYD containing 2; NACHT, LRR and PYD containing protein 2; NACHT, LRR and PYD domains-containing protein 2; NALP2; NBS1; NLR family pyrin domain containing 2; NLR family, pyrin domain containing 2; NLRP2; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2; nucleotide-binding site protein 1; PAN1; PYPAF2; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2; similar to NACHT, leucine rich repeat and PYD containing 2
Gene Symbols NLRP2
Host Species Rabbit
Immunogen A peptide corresponding to 12 amino acids near the carboxy terminus of human NALP2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 232827, 55655, 684545
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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