Naloxone hydrochloride, 98%, Thermo Scientific™

Description

Naloxone hydrochloride, CAS # 357-08-4, is involved in the blockade of the mu-opioid receptor and removal of other compounds from the receptor site.

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• Naloxone hydrochloride the hydrochloride salt of the anti-opioid naloxone

• Naloxone reverses characteristic opioid effects including euphoria, bradycardia, sedation, and respiratory depression

Application

• Naloxone is a fast-acting inverse agonist of the mu-opioid receptor that can be used to competitively inhibit the binding of opioid compounds

• Naloxone is appropriate for use in in vivo and in vitro studies of opioid receptor signaling

Specifications

Chemical Identifiers

• CAS: 357-08-4
• Molecular Formula: C19H22ClNO4
• Molecular Weight (g/mol): 363.838
• MDL Number: MFCD00069322
• InChI Key: RGPDIGOSVORSAK-STHHAXOLSA-N
• Synonym: naloxone hydrochloride, naloxone hcl, narcan, evzio, unii-f850569pqr, nalonee, 17-allyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride, narcan tn, naloxonehydrochloride
• PubChem CID: 5464092
• IUPAC Name: (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride
• SMILES: C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O.Cl

• Quantity: 1g
• Merck Index: 14,6362
• Solubility Information: Soluble in water (73mg/ml),ethanol (3.3mg/ml),methanol (50mg/ml) and dimethyl sulfoxide (73mg/ml). Insoluble in ether
• Formula Weight: 363.84
• Percent Purity: 98%
• Chemical Name or Material: Naloxone hydrochloride

RUO – Research Use Only