Invitrogen™ N4BP2L2 Monoclonal Antibody (OTI5C5)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA526656

Product Code. 15906254

Description

N4BP2L2 Monoclonal Antibody for IHC (P)

N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein that potentially is involved in transcriptional regulation. N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, probably by ATM or ATR. Primarily expressed in bone marrow, N4BP2L2 is dramatically down-regulated after exposure to arsenic compounds, an event which precedes neutropenia. PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, two proteins that are implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase, ELA2, are the cause of cyclic haematopoiesis, which, with decreased numbers of circulating neutrophils, leads to an increased risk for opportunistic infection.

Specifications

• Antigen: N4BP2L2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q92802
• Gene Symbols: N4BP2L2
• Immunogen: Full length human recombinant protein of N4BP2L2 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin)
• Clone: OTI5C5
• Conjugate: Unconjugated
• Gene: N4BP2L2
• Gene Alias: 2700092H06Rik; 92M18.3; CG005; CG016; N4BP2L2; NEDD4 binding protein 2 like 2; NEDD4 binding protein 2-like 2; NEDD4-binding protein 2-like 2; PFAAP5; phosphonoformate immuno-associated protein 5; Phosphonoformate immuno-associated protein 5 homolog; protein from BRCA2 region; zag1
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10443
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid