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Invitrogen™ N-WASP Polyclonal Antibody
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Product Code. 16539011
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Quantity:
100 μL
Unit Size:
100µL
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16539011 100 μL 100µL
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Product Code. 16539011 Supplier Invitrogen™ Supplier No. PA596170

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MSSVQQQPPP PRRVTNVGSL LLTPQENESL FTFLGKKCVT MSSAVVQLYA ADRNCMWSKK CSGVACLVKD NPQRSYFLRI FDIKDGKLLW EQELYNNFVY NSPRGYFHTF AGDTCQVALN FANEEEAKKF RKAVTDLLGR RQRKSEKRRD PPNGPNLPMA TVDIKNPEIT TNRFYGPQVN NISHTKEKKK GKAKKKRLTK ADIGTPSNFQ HIGHVGWDPN TGFDLNNLDP ELKNLFDMCG ISEAQLKDRE; Positive Samples: HeLa, U-87MG, A-549, Mouse brain, Mouse lung, Rat brain; Cellular Location: Cytoplasm, Nucleus, cytoskeleton.

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.
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Specifications

Antigen N-WASP
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.51 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene WASL
Gene Accession No. O00401, O08816, Q91YD9
Gene Alias 2900021I12Rik; 3110031I02Rik; DKFZp779G0847; MGC48327; n wasp; neural Wiskott-Aldrich syndrome protein; NWASP; N-WASP; TRS4; WASL; WASP like actin nucleation promoting factor; WASPB; Wiskott-Aldrich syndrome like; Wiskott-Aldrich syndrome-like; Wiskott-Aldrich syndrome-like (human)
Gene Symbols WASL
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 682507, 73178, 8976
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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