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  6. N-Methoxycarbonyl-L-tert-leucine, 98%

N-Methoxycarbonyl-L-tert-leucine, 98%

Product Code. 15437477
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Product Code. 15437477

Brand: Thermo Scientific Alfa Aesar H35148.03

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Description

CAS: 162537-11-3 | C8H15NO4 | 189.21 g/mol

The coupling of the two key intermediates, N-(methoxycarbonyl)-l-tert-leucine acylated benzyl hydrazine and chloromethyl ketone, via an S N 2 reaction furnished the amino ketone in high yield under our optimized conditions in practical synthesis of the HIV Protease Inhibitor Atazanavir via a Highly diastereoselective Reduction Approach.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
The coupling of the two key intermediates, N-(methoxycarbonyl)-l-tert-leucine acylated benzyl hydrazine and chloromethyl ketone, via an S N 2 reaction furnished the amino ketone in high yield under our optimized conditions in practical synthesis of the HIV Protease Inhibitor Atazanavir via a Highly diastereoselective Reduction Approach.

Solubility
Soluble in ethyl acetate and methanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, heat.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 162537-11-3
Molecular Formula C8H15NO4
Molecular Weight (g/mol) 189.21
MDL Number MFCD07778455
InChI Key NWPRXAIYBULIEI-MLHKIVSYNA-N
Synonym methoxycarbonyl-l-tert-leucine, n-methoxycarbonyl-l-tert-leucine, s-2-methoxycarbonyl amino-3,3-dimethylbutanoic acid, s-n-methoxycarbonyl-tert-leucine, n-methoxycarbonyl-3-methyl-l-valine, l-valine, n-methoxycarbonyl-3-methyl, 2s-2-methoxycarbonyl amino-3,3-dimethylbutanoic acid, s-2-methoxycarbonylamino-3,3-dimethylbutanoic acid, moc-l-tert-leucine
PubChem CID 11263950
IUPAC Name (2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid
SMILES COC(=O)N[C@H](C(O)=O)C(C)(C)C

Specifications

Melting Point 107°C to 110°C
Quantity 1 g
Solubility Information Soluble in ethyl acetate and methanol.
Formula Weight 189.21
Percent Purity 98%
Chemical Name or Material N-Methoxycarbonyl-L-tert-leucine

RUO – Research Use Only

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