Invitrogen™ N-cadherin Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA587436

Product Code. 16535921

Description

Immunogen sequence: NPKIIRQEEG LHAGTMLTTF TAQDPDRYMQ QNIRYTKLSD PANWLKIDPV NGQITTIAVL DRESPNVKNN IYNATFLASD NGIPPMSGTG TLQIYLLDIN DNAPQVLPQE AETCETPDPN SINITALDYD IDPNAGPFAF DLPLSPVTIK RNWTITRLNG DFAQLNLKIK FLEAGIYEVP IIITDSGNPP KSNISILRVK VCQCDSNGDC TDVDRIVGAG LGTGAIIAIL LCIIILLILV LMFVVWMKRR DKERQAKQLL IDPEDDVRDN ILKYDEEGGG EEDQDYDLSQ LQQPDTVEPD A Positive Samples: Mouse brain, Mouse heart, Rat heart; Cellular Location: Cell membrane, Single-pass type I membrane protein.

N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.

Specifications

• Antigen: N-cadherin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDH2
• Gene Alias: bib; cadherin 2; cadherin 2 L homeolog; cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, neuronal; cadherin 2, type 1 preproprotein; cadherin 2, type 1, N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal) L homeolog; cadherin 2, type 1, N-cadherin a (neuronal); Cadherin2; cadherin-2; Cadherin-2A; Cadherin-N; calcium-dependent adhesion protein, neuronal; CD325; CDH2; cdh2.L; cdh2a; cdh2-a; cdh2-b; CDHN; cdhn-a; CDw325; CDw325 antigen; cell adhesion molecule; glass onion; glo; I79_014914; labyrinth; lyr; NCAD; N-Cad; N-cadherin; N-cadherin 1; N-cadherin A; N-cadherin precursor; N-cadherin-2; neural cadherin; Neural cadherin A; neural cadherin-2; neural calcium-dependent cell adhesion molecule; neural-cadherin; pac; Parachute; unnamed protein product; wu:fb47h04; XELAEV_18031953mg; ZNCAD
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1000, 12558, 83501
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.3 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P15116, P19022, Q9Z1Y3
• Gene Symbols: CDH2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 500-800 of human N-Cadherin (NP_0017832).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG