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Musashi-1, clone: 14H1, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9896-82

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15258217

  • £151.12 / 100µg


Estimated Shipment
30-07-2018
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Description

Description

Description: This 14H1 monoclonal antibody recognizes human Musashi-1 (MSI-1), a 39kDa RNA binding protein. Musashi-1 is expressed in CNS stem and progenitor cells with decreased expression in differentiating cells. Musashi-1 functions as a translational repressor, directly regulating its target proteins, Numb and p21 (CIP1). Musashi-1 has been shown to be expressed in stem cells in a variety of other tissues such as the gut, stomach, mammary gland, and hair follicles. In addition to normal tissue expression, Musashi-1 expression has been identified in cells from several tumor types, mainly pulmonary and adenocarcinoma, as well as large and small cell carcinomas. Recently, expression of Musashi-1 in ischemic lesions following stroke provides evidence for neurogenesis as well as the role of Musashi-1 in regulating apoptosis. Musashi-1 is highly conserved and the 14H1 antibody also recognizes mouse and rat Musashi-1.Applications Reported: This 14H1 antibody has been reported for use in immunoblotting (WB), immunohistology staining of paraffin embedded tissue sections, and immunocytochemistry.Applications Tested: This 14H1 antibody has been tested by immunofluorescent staining of paraformaldehyde fixed and permeabilized cells. This can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Musashi-1
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q61474, Q8K3P4, O43347
Msi1
IgG2a
100μg
Store at 2-8°C. Avoid repeated freeze/thaw cycles.
Primary
4440
ImmunocytochemistryþImmunohistochemistryþWestern Blot
14H1
Unconjugated
MSI1
Purified
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
HumanþMurineþRat
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