Invitrogen™ MTSS1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5112617

Product Code. 17180474

Description

MTSS1 Polyclonal Antibody for Western Blot, IHC (P), ELISA

Metastasis suppressor protein 1 (MTSS1) [MIM, missing in metastasis], was first discovered as missing transcripts from metastatic bladder and prostate cancer cells. MTSS1 is a 755 amino acid protein, having multidomain and scaffolding function. It has a proline-rich/SH3 binding region and a serine-rich region with EGF or PDGF/Src consensus sites. It contains anactin-binding Wiskott-Aldrich syndrome protein homology-2 motif (WH2) at the C-terminus while the N-terminal IMD domain (IRSp53-MIM domain) interact with membranes and bundle actin filament. The WH2 domain binds to actin monomers and plays an important role in actin cytoskeleton reorganization. Recently, MIM was found to interact with cortactin via SH3 domains. In addition, MTSS1 enhanced cortactin- and Arp2/3-dependent actin polymerization. It is thus involved in cell motility and morphogenesis and also interacts with sonic hedgehog/Gli signaling in epidermal cells. MTSS1 acts as an important regulator of cell growth and development and is known to express in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.

Specifications

• Antigen: MTSS1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MTSS1
• Gene Alias: 2310003N14Rik; actin monomer-binding protein; BC024131; D130001D01Rik; hypothetical protein; KIAA0429; metastasis suppressor 1; metastasis suppressor protein 1; Metastasis suppressor YGL-1; Mim; MIMA; MIMB; missing in metastasis protein; mKIAA0429; MTSS I-BAR domain containing 1; MTSS1; MTSS1, I-BAR domain containing; Protein MTSS 1; protein MTSS 1; metastasis suppressor protein 1
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 9788
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 3.84 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: O43312
• Gene Symbols: MTSS1
• Immunogen: Recombinant Human Metastasis suppressor protein 1 protein (616-730AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG