MTA2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA519978

Product Code. 12828192

Description

In Western blot applications, this antibody detects a band at ∽75kDa. A suggested positive control is Hela cell lysate. PA5-19978 can be used with blocking peptide PEP-0102.

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.

Specifications

• Antigen: MTA2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mta2
• Gene Alias: AW550797; DKFZp686F2281; Mata1l1; metastais-associated gene family, member 2; metastasis associated 1 family member 2; metastasis associated 1 family, member 2; metastasis associated 1-like 1; metastasis -associated gene 1-like 1; metastasis associated gene family, member 2; metastasis-associated 1-like 1; metastasis-associated gene family, member 2; metastasis-associated protein 2; metastasis-associated protein MTA2; mmta2; Mta1l1; MTA1-L1 protein; Mta2; p53 target protein in deacetylase complex; PID
• Host Species: Rabbit
• Purification Method: Anitgen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23942, 361724, 9219
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: O94776, Q9R190
• Gene Symbols: Mta2
• Immunogen: A synthetic peptide corresponding to amino acids 652 to 668 of human PID (6)
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG