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Invitrogen™ MTA2 Polyclonal Antibody
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Product Code. 11564570
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Quantity:
100 μg
Unit Size:
100µg
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11564570 100 μg 100µg
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Product Code. 11564570 Supplier Invitrogen™ Supplier No. PA141581

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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with mouse, rat, canine, bovine, and xenopus samples based on sequence homology. Suggested positive control: Jurkat cell lysate. Predicted cross-reactivity based on sequence identity: Dog/Bovine (88%) and Xenopus (76%).

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MTA2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide
Gene Mta2
Gene Accession No. O94776, Q9R190
Gene Alias AW550797; DKFZp686F2281; Mata1l1; metastais-associated gene family, member 2; metastasis associated 1 family member 2; metastasis associated 1 family, member 2; metastasis associated 1-like 1; metastasis -associated gene 1-like 1; metastasis associated gene family, member 2; metastasis-associated 1-like 1; metastasis-associated gene family, member 2; metastasis-associated protein 2; metastasis-associated protein MTA2; mmta2; Mta1l1; MTA1-L1 protein; Mta2; p53 target protein in deacetylase complex; PID
Gene Symbols Mta2
Host Species Rabbit
Immunogen A portion of amino acids 650-700 of human MTA2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23942, 361724, 9219
Target Species Human, Mouse, Rat, Monkey
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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