missing translation for 'onlineSavingsMsg'
Learn More

MST2 Polyclonal Antibody, Invitrogen™

Goat Polyclonal Antibody

Brand:  Invitrogen PA5142855

Additional Details : Weight : 0.01000kg

Product Code. 17836352

  • £370.00 / 100µL
Estimated Shipment: 06-08-2024
to see stock.

Description

Description

Additional Information: This antibody is not expected to cross-react to STK4. This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

STK3 (MST2) is a STE kinase family member that acts upstream of the MAP kinase signaling pathways, and is known to be activated by the proapoptotic stimuli staurosporine and FAS ligand. STK3 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.
Specifications

Specifications

MST2
Polyclonal
Unconjugated
STK3
0610042I06Rik; KB-1458E12.1; KRS1; Mammalian STE20-like protein kinase 2; mess1; MST; Mst2; MST-2; MST2/C; MST2/N; Mst3; protein kinase homolog; serine/threonine kinase 3; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); serine/threonine-protein kinase 3; Serine/threonine-protein kinase 3 20kDa subunit; Serine/threonine-protein kinase 3 36kDa subunit; Serine/threonine-protein kinase Krs-1; Ste20; STE20-like kinase MST2; STK3; wu:fc19e11; zgc:55383
Goat
Ammonium sulfate precipitation
RUO
56274, 6788
-20° C, Avoid Freeze/Thaw Cycles
IgG
Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Q13188, Q9JI10
STK3
Peptide with sequence DFKNKSHENCNQN.
100 μg
Primary
Human, Mouse
Liquid
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers