Invitrogen™ MSL1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA554826

Product Code. 15782751

Description

Immunogen sequence: FGSTERKTPV KKLAPEFSKV KTKTPKHSPI KEEPCGSLSE TVCKRELRSQ ETPEKPRSSV DTPPRLSTPQ KGPSTHPKEK AFSSEIEDLP YLSTTEMY Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 95%.

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). [UniProt].

Specifications

• Antigen: MSL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MSL1
• Gene Alias: 2810017F12Rik; 4121402D02Rik; 4930463F05Rik; AA682082; hampin; hMSL1; male specific lethal 1 homolog; male-specific lethal 1 homolog; male-specific lethal 1 homolog (Drosophila); male-specific lethal 1-like 1; Male-specific lethal-1 homolog 1; Msl1; Msl-1; MSL1L1; MSL1-like 1; RGD1564778
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 339287
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q68DK7
• Gene Symbols: MSL1
• Immunogen: Recombinant protein corresponding to Human MSL1. Recombinant protein control fragment (Product #RP-93537).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG