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Invitrogen™ MSL1 Polyclonal Antibody
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Product Code. 15662985
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Quantity:
400 μL
Unit Size:
400µL
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15662985 400 μL 400µL
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Product Code. 15662985 Supplier Invitrogen™ Supplier No. PA548690

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Description

Rabbit Polyclonal Antibody

Predicted to react with mouse based on sequence homology.

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen MSL1
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene MSL1
Gene Accession No. Q68DK7
Gene Alias 2810017F12Rik; 4121402D02Rik; 4930463F05Rik; AA682082; hampin; hMSL1; male specific lethal 1 homolog; male-specific lethal 1 homolog; male-specific lethal 1 homolog (Drosophila); male-specific lethal 1-like 1; Male-specific lethal-1 homolog 1; Msl1; Msl-1; MSL1L1; MSL1-like 1; RGD1564778
Gene Symbols MSL1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 339-367 amino acids from the Central region of human MSL1.
Purification Method Antigen Affinity Chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 339287
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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