Invitrogen™ MSH3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5104405

Product Code. 16660855

Description

Antibody detects endogenous levels of total MSH3.

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Specifications

• Antigen: MSH3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MSH3
• Gene Alias: D13Em1; Divergent upstream protein; DNA mismatch repair protein Msh3; DUC1; DUG; DUP; hMSH3; Mismatch repair protein 1; MRP1; MSH3; mutS homolog 3; mutS homolog 3 (E. coli); protein repair-1; Protein repair-3; REP-1; Rep3; Rep-3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4437, 499505
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P20585
• Gene Symbols: MSH3
• Immunogen: A synthesized peptide derived from human MSH3(Accession P20585), corresponding to amino acid residues G110-F160.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG