Epredia™ Lab Vision™ MSH2 (Mismatch Repair Protein 2) Ab-1, Mouse Monoclonal Antibody

Choose one marker in a comprehensive antibody portfolio that addresses all major disease states, ensuring the ideal tests are always available.

Product Code	Brand	Quantity	Form
12619936	Epredia™ MS-1498-S0	100 μL	Concentrated
12629936	Epredia™ MS-1498-S1	500 μL	Concentrated
12609936	Epredia™ MS-1498-S	1 mL	Concentrated
12689926	Epredia™ MS-1498-R7	7 mL	Prediluted

Description

Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites/simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSβ, which binds to insertion/deletion loops in DNA.

Host Species: Mouse

Clone: 25D12

Isotype: IgG1/κ

Species Reactivity: Human. Others not tested.

Immunogen: Recombinant human MSH2 protein

Molecular Weight: ∽102kDa

Positive Control: Tonsil

Cellular Localization: Nuclear

Recommended for:

• Immunohistochemistry (Formalin/paraffin)

Specifications

• Antigen: MSH2 (Mismatch Repair Protein 2) Ab-1
• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Regulatory Status: IVD
• Immunogen: Recombinant human MSH2 protein

• Clone: 25D12
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: DNA Repair
• Primary or Secondary: Primary