MRPS12 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16814324	Proteintech 15225-1-AP-20UL	20 μL
16804324	Proteintech 15225-1-AP-150UL	150 μL

Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal domit deafness gene (DFNA4). Splice variants that differ in the 5′ UTR have been found for this gene; all three variants encode the same protein.

Specifications

• Antigen: MRPS12
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Rat, Mouse, Human
• Gene Accession No.: O15235, O35680
• Gene ID (Entrez): 24030, 292758, 6183
• Immunogen: MRPS12 Fusion Protein Ag7442
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: MRPS12

• Concentration: 0.24 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: MPR S12, MRP S12, MRPS12, MT RPS12, RPMS12, RPS12, RPSM12, S12mt
• Gene Symbols: MRPS12
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody