Invitrogen™ MRCK beta Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA536291

Product Code. 15597601

Description

This antibody detects endogenous protein at a molecular weight of 194 kDa. Purity is >95% by SDS-PAGE.

CDC42BPB is a serine/threonine kinases which functions in actin cytoskeleton assembly and organization. Myotonic dystrophy kinaserelated Cdc42-binding (DMPK-like) kinases-alpha and beta (MRCK-alpha, beta) contain a cysteine-rich motif and a putative pleckstrin homology domain. MRCKs can phosphorylate nonmuscle Myosin light chain and influences Actin-Myosin contractility. MRCK-alpha can phosphorylate and activate LIM kinases downstream of Cdc42, which leads to inactivation of ADF/Cofilin and to Actin cytoskeletal reorganization. MRCK-alpha can also influence neurite outgrowth promoted by Cdc42 and Rac.

Specifications

• Antigen: MRCK beta
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CDC42BPB
• Gene Alias: CDC42 binding protein kinase beta; CDC42 binding protein kinase beta (DMPK-like); CDC42-binding protein kinase beta; CDC42-binding protein kinase beta (DMPK-like); CDC42BPB; cdc42bpb {ECO:0000312; CDC42BP-beta; DMPK-like beta; EMBL:AAP34403.1}; Kiaa1124; MRCK beta; MRCKb; myotonic dystrophy kinase related CDC42 binding kinase beta; myotonic dystrophy kinase-related CDC42-binding kinase beta; myotonic dystrophy protein kinase like beta; myotonic dystrophy protein kinase-like beta; serine/threonine-protein kinase MRCK beta
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 113960, 217866, 9578
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q7TT49, Q7TT50, Q9Y5S2
• Gene Symbols: CDC42BPB
• Immunogen: Synthetic peptide corresponding to amino acids 1630-1680 of human MRCK beta.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG