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MPP dihydrochloride, Tocris Bioscience™
Highly selective ERα antagonist
Chemical Identifiers
| CAS | 911295-24-4 |
|---|---|
| Molecular Formula | C29H33Cl2N3O3 |
| Molecular Weight (g/mol) | 542.501 |
| InChI Key | SMPRQALBFACGGO-UHFFFAOYSA-N |
| Synonym | mpp dihydrochloride, 1,3-bis-4-hydroxyphenyl-4-methyl-5-4-2-piperidinylethoxy phenol-1h-pyrazole dihydrochloride, mpp dihydrochloride hydrate, methyl-piperidino-pyrazole hydrate, 1,3-bis 4-hydroxyphenyl-4-methyl-5-4-2-piperidinylethoxy phenol-1h-pyrazole dihydrochloride, mpp dihydrochloride hydrate hplc , white powder, 1,3-bis 4-hydroxyphenyl-4-methyl-5-4-2-piperidinylethoxy phenol-1h-pyrazole dihydrochloride hydrate, 4-1-4-hydroxyphenyl-4-methyl-5-4-2-piperidin-1-yl ethoxy phenyl-1,2-dihydro-3h-pyrazol-3-ylidene cyclohexa-2,5-dien-1-one-hydrogen chloride 1/2, 4-3-4-hydroxyphenyl-4-methyl-5-4-2-piperidin-1-yl ethoxy phenyl pyrazol-1-yl phenol dihydrochloride |
| PubChem CID | 45073474 |
| IUPAC Name | 4-[2-(4-hydroxyphenyl)-4-methyl-3-[4-(2-piperidin-1-ylethoxy)phenyl]-1H-pyrazol-5-ylidene]cyclohexa-2,5-dien-1-one;dihydrochloride |
| SMILES | CC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)OCCN5CCCCC5.Cl.Cl |
Description
Selective, high affinity silent antagonist at ERα receptors. Displays > 200-fold selectivity for ERα over ERβ. Ki values are 2.7 and 1800 nM at ERα and ERβ receptors respectively.Chemical Identifiers
| 911295-24-4 | |
| 542.501 | |
| mpp dihydrochloride, 1,3-bis-4-hydroxyphenyl-4-methyl-5-4-2-piperidinylethoxy phenol-1h-pyrazole dihydrochloride, mpp dihydrochloride hydrate, methyl-piperidino-pyrazole hydrate, 1,3-bis 4-hydroxyphenyl-4-methyl-5-4-2-piperidinylethoxy phenol-1h-pyrazole dihydrochloride, mpp dihydrochloride hydrate hplc , white powder, 1,3-bis 4-hydroxyphenyl-4-methyl-5-4-2-piperidinylethoxy phenol-1h-pyrazole dihydrochloride hydrate, 4-1-4-hydroxyphenyl-4-methyl-5-4-2-piperidin-1-yl ethoxy phenyl-1,2-dihydro-3h-pyrazol-3-ylidene cyclohexa-2,5-dien-1-one-hydrogen chloride 1/2, 4-3-4-hydroxyphenyl-4-methyl-5-4-2-piperidin-1-yl ethoxy phenyl pyrazol-1-yl phenol dihydrochloride | |
| 4-[2-(4-hydroxyphenyl)-4-methyl-3-[4-(2-piperidin-1-ylethoxy)phenyl]-1H-pyrazol-5-ylidene]cyclohexa-2,5-dien-1-one;dihydrochloride |
| C29H33Cl2N3O3 | |
| SMPRQALBFACGGO-UHFFFAOYSA-N | |
| 45073474 | |
| CC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)OCCN5CCCCC5.Cl.Cl |
Specifications
| 911295-24-4 | |
| mpp dihydrochloride, 1,3-bis-4-hydroxyphenyl-4-methyl-5-4-2-piperidinylethoxy phenol-1h-pyrazole dihydrochloride, mpp dihydrochloride hydrate, methyl-piperidino-pyrazole hydrate, 1,3-bis 4-hydroxyphenyl-4-methyl-5-4-2-piperidinylethoxy phenol-1h-pyrazole dihydrochloride, mpp dihydrochloride hydrate hplc , white powder, 1,3-bis 4-hydroxyphenyl-4-methyl-5-4-2-piperidinylethoxy phenol-1h-pyrazole dihydrochloride hydrate, 4-1-4-hydroxyphenyl-4-methyl-5-4-2-piperidin-1-yl ethoxy phenyl-1,2-dihydro-3h-pyrazol-3-ylidene cyclohexa-2,5-dien-1-one-hydrogen chloride 1/2, 4-3-4-hydroxyphenyl-4-methyl-5-4-2-piperidin-1-yl ethoxy phenyl pyrazol-1-yl phenol dihydrochloride | |
| CC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)OCCN5CCCCC5.Cl.Cl | |
| 542.501 | |
| 542.5 | |
| MPP dihydrochloride |
| C29H33Cl2N3O3 | |
| SMPRQALBFACGGO-UHFFFAOYSA-N | |
| 4-[2-(4-hydroxyphenyl)-4-methyl-3-[4-(2-piperidin-1-ylethoxy)phenyl]-1H-pyrazol-5-ylidene]cyclohexa-2,5-dien-1-one;dihydrochloride | |
| 45073474 | |
| >98% |
Safety and Handling
Recommended Storage : Desiccate at +4°C