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Tocris Bioscience™ MPD 2

Product Code. 30279879
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5 mg
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Product Code. 30279879

Brand: Tocris Bioscience™ 8802/5

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This item is not returnable. View return policy

Description

SARS-CoV-2 Mpro Degrader (PROTAC™)

MPD 2 is a SARS-CoV-2 Mpro Degrader (PROTAC™) (DC50 = 296 nM in 293T cells). Mpro degradation is time-dependent and CRBN-mediated. Antiviral in A549-ACE2 cells infected with several SARS-CoV-2 strains (EC50 = 492 nM at delta variant) and against a nirmatrelvir-resistant mutant of SARS-CoV-2, NSP5 E166A (EC50 = 460 nM).

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 3-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)oxy)benzyl ((2S,3R)-3-(tert-butoxy)-1-(((S)-3-cyclohexyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)propan-2-yl)amino)-1-oxobutan-2-yl)carbamate
Quantity 5 mg
Target Active Degraders
Molecular Formula C51H68N6O13
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