ACROBiosystems Mouse TIGIT Protein, Fc Tag

Product Code.	Quantity	unitSize
15847787	1 mg	1mg
15857787	50 μg	50µg

Product Code. 15847787 Supplier ACROBiosystems Supplier No. TITM52571MG

Description

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 39.5 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE).

Specifications

• Accession Number: NP_001139797.1
• Molecular Weight (g/mol): 39.5 kDa
• Quantity: 1 mg
• Source: Mouse TIGIT, Fc Tag (TIT-M5257) is expressed from human 293 cells (HEK293). It contains AA Gly 26 - Thr 143 (Accession # NP_001139797.1).
• Immunogen: Gly 26 - Thr 143
• Storage Requirements: -20°C
• Gene Alias: TIGIT,VSIG9,VSTM3
• Common Name: TIGIT
• Conjugate: Unconjugated
• Species: Mouse
• Protein Tag: Fc Tag
• Buffer: Tris with Glycine, Arginine and NaCl, pH7.5
• Endotoxin Level: Less than 1.0 EU / μg by the LAL method.
• Expression System: HEK293
• Form: Powder
• Protein Subtype: Immune Checkpoint Proteins
• Purity or Quality Grade: >95% as determined by SDS-PAGE